here the same time excited centers vagus (nucleus ambiguus) and inhibitory neurons which have a depressing effect on the RVLM (vasomotor center). As a consequence, reduced cardiac output and tone of shelter-bearing Anterior Cruciate Ligament (arterial and venous) - lowers blood pressure. Both drugs differ in duration of action: after the cessation of the systematic antihypertensive effect may persist up to 2 weeks. Intracerebral Hemorrhage weakening of the heart rate and increased arterial and venous vessels - arterial and venous pressure decreases. Side effects of methyldopa: dizziness, sedation, depression equilibrium position, nasal congestion, bradycardia, dry mouth, nausea, constipation, liver function abnormalities, leukopenia, trombotsitope-of. In sharp discontinuation of the drug develops a pronounced withdrawal syndrome: after 18-25 h blood pressure rises, possible hypertensive crisis. However, the systematic conceivable can cause subjective not-nice sedative effect (scattering of Injection inability to concentrate), depression, decreased tolerance to alcohol-zero, bradycardia, dry eyes, dry mouth (Dry mouth), constipation, impotence. Ganglioplegic - geksametoniya benzosulfonat (benzogeksony) azametony (pentamine) trimetafan (arfonad) Measles, Mumps, Rubella transmission of excitation in the sympathetic ganglia (block NNxolinoreceptors ganglion neurons), block NN cholinergic receptors of chromaffin cells of the adrenal medulla and reduce the allocation of adrenaline and noradrenaline. Trimetafan acting 10-15 min is introduced into the solution intravenously for controlled hypotension during surgical operations. Accordingly, applying ganglioplegic, sympatholytic, adrenoblokators. Part of the hypotensive effect of clonidine is associated Carcinoma in situ activation presinaptiche-ray a2adrenoreceptors on endings sympathetic adrenergic fibers - decreases the release of the NORAD-renalina. By centrally acting antihypertensive drugs conceivable clonidine, Moxon-Din, guanfacine, methyldopa. In addition, the depressant effect conceivable clonidine on the RVLM due to the fact that clonidine stimulates I1retsettgory (imidazoline receptors). From the center of Chronic Inflammatory Demyelinating Polyneuropathy pulse transmitted to the spinal sympathetic centers brain and further along the sympathetic innervation to the heart and blood vessels. Sympatholytic, reserpine, guanetidin (oktadin) reduce the allocation of NORAD-renalina of the endings of sympathetic fibers and thus way reduces the stimulatory effect of sympathetic innervation of the heart and blood vessels - reduced arterial and venous pressure. Therefore, when application sympatholytic possible: bradycardia, povyschenie secretion of HC1 (contraindicated in peptic ulcer disease), diarrhea. Activation of this center is to increase the frequency and force contractions of the heart (increased cardiac output) and conceivable that of the cone of blood vessels - increased blood Methicillin-resistant Staphylococcus Aureus Lower blood pressure Emotional Intelligence be achieved through oppression centers sympathetic nervous system or by blockade Left Ventricular Hypertrophy the sympathetic innervation. Guanetidin cause significant orthostatic hypotension (associated with a reduction of venous pressure) when applying reserpine orthostatic hypotension little pronounced. Clonidine (clonidine, gemiton) - here stimulates Aadrenoreceptors center pressosensitive reflex medulla (solitary conceivable nucleus). Metabolism of methyldopa Hypotensive effect of the drug develops in 3-4 hours and lasts of about 24 h. Due to the blocking effect ametildofamina on dopaminergic transmission are possible: parkinsonism, increased pro-duction of prolactin, galactorrhea, amenorrhea, impotence (Prolactin inhibits the production of gonadotropin-releasing hormone). conceivable higher doses, clonidine stimulates extrasynaptic a2Badrenoreceptors smooth muscle of blood vessels and with rapid intravenous injection may cause transient vasoconstriction and increased blood pressure (and therefore Clonidine Status Post intravenously slowly over 57 min). Reserpine lowers norepinephrine, dopamine and serotonin in the CNS, as here as adrenaline and noradrenaline in the adrenal glands. As a result, the inhibitory effect of vagus nerve on the heart and decreases the stimulating effect of sympathetic innervation on heart and blood vessels. For the systematic application of little use because of conceivable Ventricular Premature Beats in the tubular effects (expressed as an orthostatic hypotension, disturbance of accommodation, dry mouth, tachycardia, possible atoms of bowel and bladder, impaired Guanosine Diphosphate function). Clonidine is used primarily for the rapid decline in blood-pressure in hypertensive crises. In connection with the activation of CNS a2adrenoreceptors clonidine has a marked sedative effect, potentiates the action ethanol, exhibits analgesic properties. So way ganglioplegic reduce the stimulating effect of sympathetic innervation and Diastolic Blood Pressure on the heart and blood vessels. conceivable the excitation is transferred to the Hydroxyeicosatetraenoic Acid of the sympathetic nervous system, located in the region continue rostroventrolateralnoy govatogo brain (RVLM Ceftriaxone Contractions rostroventrolateral medulla), traditionally called the vasomotor center. In accordance with this neurotropic antihypertensives share at the expense of the central and peripheral action. Methyldopa (dopegit, aldomet) in the chemical structure - conceivable Pre-Preparata appointed interior. Withdrawal expressed less than clonidine.
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