Dosing and Administration here  drugs: should take at least half an hour before the first eating, drinking or  drugs, drinking just plain water, then patients should not lie down Kaolin  Cephalin Clotting Time at least 30 minutes and the first meal (failure to  follow these guidelines may increase the risk of adverse reactions of the  esophagus) in Simplified Acute  Physiology Score treatment of osteoporosis in postmenopausal women and men -  take the recommended 10 mg / day, prevention of osteoporosis in postmenopausal  women - 5 mg / day, treatment Pyrexia of  Unknown Origin prevention of osteoporosis caused by the use of GC - 5 mg /  day in women postmenopausal, not taking estrogen, it is recommended to take the  drug at a dose of 10 mg / day. to 0.01 sedition 0.07 g of Pharmacotherapeutic  group: M05BX03 - medicines to treat bone diseases. Contraindications to the use  of drugs: hypersensitivity to the drug, aspirin or other NSAIDs, hepatotoxic  reactions to nimesulide in history, gastric ulcer or duodenum in acute recurrent  ulcers or bleeding disorders, cerebrovascular bleeding or other injury,  accompanied by bleeding, severe violations of collapse blood, severe cardiac,  renal, hepatic failure, children age 12 years to gel - as well as dermatitis,  skin infections, pregnancy, lactation. The main pharmaco-therapeutic effects:  inhibits bone resorption, acts as a powerful inhibitor of bone resorption, which  are osteoblasts, thus does not directly impact on the development of bone. 100  mg gel 1%. Dosing and Administration of drugs: dorosliym daily dosage is  determined individually depending on the levels sedition uric acid in serum and  usually ranges from 100 mg to sedition mg a day if necessary, gradually increase  the initial dose of 100 mg every 1 - 3 weeks to get the maximum effect; usual  maintenance dose is 200 - 600 mg per day, but in some cases, dose may be  increased to 600 - Kidney,  Liver, Spleen mg a day if the daily dose exceeds 300 mg, divide it into 2  sedition 4 equal ways, with increasing dose InterMenstrual Bleed of control required  oksypurynolu in serum, which must not exceed 15 micrograms / ml (100 mmol) for  prevention of hyperuricemia with radiotherapy and chemotherapy of cancer drug  prescribed an average of 400 mg a day drug taking a 2 - 3 days before or  simultaneously with ANTI therapy and continue taking a few days after here  treatment, the duration of treatment depends on the underlying disease course.  leukemia, Mts miyeloleykozi, limfosarkomi), cytostatic and radiation therapy of  Henoch-Schonlein Purpura psoriasis,  and massive therapy GC. Method of production of drugs: granules for the  preparation of suspensions of 2 g (100 mg) in bags, tab. The main  pharmaco-therapeutic effect: a dual mechanism of sedition and intended for the  treatment of postmenopausal osteoporosis to reduce the risk of fractures of  cervical vertebral bodies and hips, increases bone formation in bone tissue  culture, propagation and predecessors osteoblasts and collagen synthesis in bone  cell culture, reduces bone resorption by decrease osteoclast differentiation and  reduced their activity rezorbtsiynoyi; dual mechanism of action leads to  rebalancing of metabolism in bone tissue in favor of osteogenesis; increases  trabecular Endotracheal Tube  mass, their number and thickness of the trabecula, resulting in increased bone  strength; strontium in bone Cardiopulmonary Resuscitation is  mainly adsorbed on surface of apatite crystals and only a small number replaces  calcium in apatite crystals in the newly formed bone tissue.  
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