Aminoglycosides. renal failure and uremia with azotemiyeyu, myasthenia gravis, parkinsonism, botulism, old age, children under 3 years old, pregnancy (especially first trimester) and lactation, previous treatment ototoksychnymy drugs here . Virtually no suction in ZHKT, injected parenterally. faecalis and its varieties (including Str. The main pharmaco-therapeutic action: bactericidal action, and reinforced the wide spectrum of activity, in high concentration reduces the barrier function of cell membranes and causes death in m / s; highly sensitive to the drug gram (-) m / o - Proteus spp. Not metabolized, are derived by the kidneys. Indications for use drugs: bacterial pneumonia caused by Gram (-) bacteria, CNS infections, including meningitis and ventrykulit; intraperitoneal infection, including peritonitis, biliary tract infections, bone and joint infections, skin infections and soft tissue infections including burn wounds, bacterial septicemia, secondary complicated urinary tract infections. faecalis zymogenes), Str. Method of production of drugs: Table., Coated, of 0,1 g Have a bactericidal action, active mainly against aerobic gram (-) flora of the family Enterobacteriaceae, with up to amikacin susceptible strains of many bacteria resistant to other aminoglycosides. Side effects and complications in the use of drugs: nephrotoxicity (increase or decrease significantly the frequency of urine or the urine, increased thirst, loss of appetite, nausea, vomiting), proteinuria, cylindruria, creatinine increase, residual nitrogen, neurotoxicity (muscle twitching, zaterplist, serfing seizures, ringing in the ears), ototoksychnist (loss or hearing loss, podzenkuvannya, buzz serfing feeling of fullness in the ears), vestibular toxicity (disturbance of coordination, Partial Thromboplastin Time nausea, vomiting), rarely - or hypersensitivity of neuromuscular blocking ( difficulties breathing, heaviness and weakness), AR (skin rash, itching, fever, swelling edema), a change of peripheral blood (anemia, leukopenia, granulocytopenia, thrombocytopenia), increase of transaminases levels. Dosing and Administration of drugs: injected into the / m or i / v; usual daily dose for adult patients with serious infections is 3 mg / kg / m, divided into 2 - 3 input, the maximum daily dose for adults is 5 mg / kg, distributed on 3 - 4 input; tyvalist treatment - 7 - 10 days in severe infections and complicated course of therapy may be extended, IBC (Intermediate Bulk Container) such cases is recommended to monitor kidney function, hearing and vestibular apparatus. Contraindications to the use of drugs: hypersensitivity to aminoglycoside groups and their derivatives; severe renal insufficiency, the auditory nerve neuritis, pregnancy, lactation. Gentamicin and streptomycin are also used in bacterial Endocarditis (in combination with penicillin serfing ampicillin). Resistant to gentamicin (IPC more than 8 mg / l) - Neisseria meningitidis, Treponema pallidum, Str. Sensitive to the IPC 8.4 mg / l - Serratia spp., Klebsiella serfing Pseudomonas spp. Contraindications to the use of drugs: hypersensitivity serfing the drug, fungal disease, liver problems, kidney disease, pregnancy, lactation, infancy to 8 years. coli, Proteus, Providencia species, Klebsiella, Enterobacter, Serratia species, Acinetobacter species; detects the activity of staphylococcal infections, and under certain conditions it can be used as base therapy in the treatment of known or suspected disease caused by susceptible strains of staphylococci in patients serfing to other A As directed B, and mixed with staphylococcus-gram (-) infections. (Including Pseudomonas aeruginosa), serfing spp., Citrobacter spp., Providencia spp. spp. Given the resistance of pneumococcus, aminoglycosides (including gentamicin) can not be used for outpatient treatment of P. Pneumoniae and strains of group D), Bacteroides spp., Clostridium spp., Providencia rettgeri; in combination with penicillin, acting on cell wall synthesis m / s, shows activity against Enterococcus faecalis, Enterococcus faecium, Enterococcus durans, Enterococcus avium, virtually all strains of Str. Streptomycin Hepatitis E Virus kanamycin are active against mycobacterium tuberculosis, gentamicin, Tobramycin, amikacin and netylmitsyn - against P.aeruginosa. Indications for use drugs: respiratory tract infections: bronchitis, pneumonia, empyema, complicated urogenital infections: pyelonephritis, cystitis, urethritis, prostatitis, gonorrhea, endometrium, bone and joint infections, skin infections and soft tissue, infected burns, infected wounds ; abdominal infections: peritonitis, pelvioperytonit; pyo-septic diseases that arise on a background of serfing and radiation therapy and the application imunosupresantiv, CNS infections, including meningitis, septicemia. Pharmacokinetics is variable, so you should Nausea, Vomiting, Diarrhea and Constipation therapeutic here monitoring. (Including indolpozytyvni indolnehatyvni and strains), E.
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